Screening for cognitive dysfunction in neurodegenerative illness.

Coma, delirium, and cognitive dysfunction in critical illness.

Syndromes of global cerebral dysfunction that are associated with critical illness include acute disorders (eg, coma, delirium) and chronic processes (ie, cognitive impairment). These syndromes can result from direct cerebral injury; however, many cases develop as a complication of a systemic insult. Coma frequently evolves into phenomenologically distinct disorders of consciousness; it must be...

Cognitive dysfunction in psychiatric illness: a neglected domain.

Mitochondrial dysfunction in neurodegenerative disorders.

There is compelling evidence for the direct involvement of mitochondria in certain neurodegenerative disorders, such as Morbus Parkinson, FRDA (Friedreich's ataxia), ALS (amyotrophic lateral sclerosis), and temporal lobe epilepsy with Ammon's horn sclerosis. This evidence includes the direct genetic evidence of pathogenic mutations in mitochondrial proteins in inherited Parkinsonism {such as PA...

Mitochondrial dysfunction in neurodegenerative diseases.

Neurodegenerative diseases are a large group of disabling disorders of the nervous system, characterized by the relative selective death of neuronal subtypes. In most cases, there is overwhelming evidence of impaired mitochondrial function as a causative factor in these diseases. More recently, evidence has emerged for impaired mitochondrial dynamics (shape, size, fission-fusion, distribution, ...

Olfactory Dysfunction in Neurodegenerative Diseases

INTRODUCTION Olfactory impairment is a common occurrence in aging and may be an early signal of neurodegenerative diseases. Olfactory loss caused by aging and diseases affects both quality of life and personal safety. Aging, as well as viral infections, neurodegenerative diseases, head injuries, chronic sinusitis infections and nasal obstructions are the most common causes of olfactory disorder...